|
KMID : 1123920180320060375
|
|
Korean Journal of Oriental Physiology and Pathology
2018 Volume.32 No. 6 p.375 ~ p.383
|
|
|
Comparative Study on the Effects of Korean and Chinese Crataegus pinnatifida on Scopolamine-induced Memory Impairment in Mice
|
|
Lee Ji-Hye
Kim Hye-Jeong
Lee Chan-Hee
Park Sang-Hyeok
Jung Chul-Jong
Beik Gyung-Yun
Shin Jin-Gi
Jung Ji-Wook
|
|
|
Abstract
|
|
|
|
This study was conducted to investigate the cognitive improvement and memory recovery effects of Korean and Chinese Crataegus pinnatifida ethanolic extracts on scopolamine-induced memory impairment in mice. In vivo studies were carried out with mice treated with Korean Crataegus pinnatifida extracts (KCF) and Chinese Crataegus pinnatifida extracts (CCF) in doses of 5 and 50 mg/kg (p.o.) and scopolamine was injected 30 min before the behavioral testing. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and acetylcholinesterase inhibition by Ellman's modified method. The chlorogenic acid and hyperoside as marker compounds of KCF and CCF was quantified by ultra-performance liquid chromatography analysis (UPLC). Results showed that KCF was more contained high content of chlorogenic acid and hyperoside than CCF. In addition, KCF was more exerted free radical (DPPH and ABTS) scavenging activity and blocked AChE activity than CCF. In vivo studies also showed that KCF administration has a further improved the memory of scopolamine-treated mice than CCF in Y-maze test, passive avoidance test and Morris water maze test. These results revealed that KCF more prevents scopolamine-induced memory impairments through antioxidant and acethylcholinesterase inhibition effect compared CCF.
|
|
|
KEYWORD
|
|
|
Crataegus pinnatifida, Scopolamine, Amnesia, Memory, Chlorogenic acid, Hyperoside
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|